Phase 1 / biological review worksheet

Target review sheet

RCSB-enriched review metadata for deciding which candidate chains enter Phase 1A and the later Phase 1B expansion.

Rows

24
Candidate chains enriched for review; 8 frozen into Phase 1A.

Review/replace

2
Low-resolution references flagged for likely replacement or explicit justification.

Diversity

6
Antibody/Fab-context rows flagged for diversity review.

Review Summary

Proposed actionCountMeaning
candidate_ok_pending_biological_review8Technically reasonable, still needs biological author approval.
review_context_dependency7Chain comes from complex, fragment, ribosome, nucleosome, or bound context.
review_for_diversity6Antibody/Fab-heavy context could overrepresent one target family.
review_reference_type1NMR reference; may be acceptable if explicitly justified.
review_or_replace2Low-resolution reference or otherwise risky primary scoring target.

Flag Counts

FlagCount
multi_protein_entry14
complex_or_fragment_context13
antibody_context6
membrane_or_transport_hint5
low_resolution_reference2
nmr_reference1

Review Files

Boundary

This page does not approve targets. It makes the biological review concrete. The triage layer identifies provisional keeps, review-needed rows, and replacement-recommended rows. The provisional keeps are now frozen as Phase 1A for execution, while external biological review remains required before final biological interpretation.