Phase 1 / biological review triage

Target review triage

A reproducible triage layer over the 24 candidate chains. The 8 provisional keeps are now computationally frozen as Phase 1A; the remaining rows stay in Phase 1B review.

Provisional keep

8
Technically clean enough if biological reviewer agrees.

Human review

14
Diversity, context dependency, or reference-type judgment needed.

Replace

2
Risky for first freeze unless reviewer overrides.

Triage Summary

Triage tierCountFreeze recommendation
provisional_keep8Keep if biological reviewer agrees.
human_review_context_dependency7Keep only if single-chain scoring remains interpretable.
human_review_diversity6Keep only if antibody/Fab weighting is intentional.
human_review_reference_type1Keep only if NMR reference is acceptable for this benchmark.
replacement_recommended2Replace before freeze unless reviewer overrides.

Provisional Keep Targets

13CZ:A, 13EE:A, 13FT:A, 9H8N:A, 9K9X:A, 9K9Y:A, 11BC:C, 12OY:A

These rows are now frozen as the Phase 1A SimpleFold-3B benchmark. This is a computational freeze, not biological approval.

Replacement Recommended

TargetReason
9H8O:ALow-resolution reference plus membrane/transport context.
21VV:ALow-resolution reference plus nucleosome, nonprotein, and complex context.

Data

Boundary

This is a computational triage, not biological approval. Phase 1A is frozen for execution, but final biological interpretation remains blocked until a domain reviewer approves or caveats the 8-target set.